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at 375degf a 1 lb meatloaf will take about 25 to 30 minutes for the meatloaf temp to reach 160degf. a 2 lb meatloaf will take about 40 to 50 minutes for the meatloaf temp to reach 160degf. a 3 lb meatloaf will take about 1 hour to 1 hour and 15 minutes for the meatloaf temp to reach 160degf.

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